| 專利摘要 |
本發明提供合適作為抗黴漿菌之次單位疫苗的活性成分的蛋白質及以其製得之疫苗。前述蛋白質經實驗證實可引發足夠強度的免疫反應而避免豬隻感染黴漿菌。前述疫苗可含有一種前述之蛋白質作為活性成分，或含有兩種以上前述之蛋白質而形成雞尾酒疫苗的形式。本發明之疫苗不僅較習用疫苗更具安全性，同時具有相當、甚至是更優異的免疫效果。此外，本發明並證實了合適於生產出具高可溶性之前述蛋白質的融合伴子，可顯著地節省生產成本。
The present invention provides proteins that are suitable to be used as the active ingredient in subunit vaccine againstMycoplasmaspp. The present invention also provides a subunit vaccine made therefrom. Said proteins have been experimentally proved to have the capability of inducing sufficient immune response to avoid pigs fromMycoplasmaspp. infection. Said vaccine may have one of said proteins as active ingredient; or may have two or more of said proteins and is formulated as a cocktail vaccine. The present vaccine not only is safer than the conventional vaccines but also has equal or even better immune efficiency than the conventional ones. Furthermore, fusion partners suitable for producing said proteins of high solubility are also proved, which can significantly reduce production cost.
|
